Fig. 2. Serological response to immunization. (A) The antibody response against to M2e peptide was measured by an ELISA using synthetic human peptides. (B) and (C) Hemagglutination inhibition (HI) serum antibody titers were measured using (B) A/California/08/2009 (H1N1pdm), or (C) A/Brisbane/59/2007. “Naïve”, unvaccinated animals; “M2e5x”, vaccinated animals with M2e5x VLPs alone; “Split”, vaccinated animals with monovalent 2009 H1N1 split inactivated virus PRT062607 alone; “Split+M2e5x”, vaccinated animals with monovalent 2009 H1N1 split inactivated virus vaccine supplemented with M2e5x VLPs. A p value <0.05 was used as the cutoff for statistical significance (* p ≤ 0.05; † p ≤ 0. 001). Error bars represent 95% confidence intervals, calculated using compound symmetry covariance to pool variability across groups. The dashed line in panels B and C represents the limit of detection (HI titers = 10).Figure optionsDownload full-size imageDownload as PowerPoint slide
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