Furthermore, correlation analysis showed that there were statistic significances of these characteristics (except gender) between the metastatic and non-metastatic subgroups (Table 1). Increased TNC expression in metastatic HCC is closely associated with higher inflammation and poor prognosis in HCC patients TNC was mainly detected in tumor cell plasma. TNC was also Quinapyramine detected in mesenchymal region including hepatic sinusoidal walls and stroma in both metastatic HCC and non-metastatic HCC groups (Figure 1A). In normal liver tissues, TNC was weakly detected in the sinusoidal walls (Figure 1A). The total TNC score (expression
density and the distribution area of TNC) in the metastatic group was higher than that of the non-metastatic group (Figure
1B; scored 4.456 �� 0.2664 and 2.502 �� 0.1931, respectively; Supplemental Table 1). The total TNC scores of the metastatic and non-metastatic group are higher than that of the normal selleck chemicals llc tissues (scored 0.588 �� 0.1043; Figure 1B). A similar TNC expression trend was found in cancer cell and in mesenchyme in both metastatic and non-metastatic groups, respectively (Supplemental Table 1). Thus, these results suggest that high TNC expression was associated with metastasis potential. Figure 1 The association of TNC Expression and inflammation in HCC patients and Kaplan-Meier survival curves for all HCC patients with different TNC expression levels. A. TNC was detected by immunohistochemistry in normal liver tissues and in HCC tissues with Capmatinib price ... To determine the relationship between inflammation and TNC expression, Knodell score system was applied to assess the inflammation level. The results showed a higher inflammation score in metastatic HCC group compared to that in the non-metastatic group (12.72
�� 3.39 and 8.58 �� 2.52, respectively; Supplemental Table 1). Correlation analysis of total TNC scores was performed. There was a close association between total TNC scores and Knodell scores (Figure 1C, spearman��s rho = 0.547, P < 0.01). Thus, TNC expression was associated with inflammation in the liver tissue in HCC patients. A post-surgery follow-up was conducted to evaluate the relationship between patient survival and TNC expression. Patients were classified into three groups according to the deposition of TNC in cancer cell or in mesenchyme: cancer cell positive/mesenchyme positive (CaC+/M+, 60 patients), cancer cell positive/mesenchyme negative (CaC+/M-, 21 patients) and cancer cell negative/mesenchyme negative (CaC-/M-, 19 patients). During the follow-up, 48 patients in CaC+/M+ group, 7 patients in CaC+/M- group and 2 patients in CaC-/M- group have died. There was a significant difference among the three groups (��2 = 29.750, P < 0.05) (see Supplemental Table 2). Kaplan-Meier survival curves indicated that patients in CaC+/M+ group had the shortest median survival time (17 months). The patients in CaC+/M- group survived longer (32 months) (Figure 1D).
density and the distribution area of TNC) in the metastatic group was higher than that of the non-metastatic group (Figure
1B; scored 4.456 �� 0.2664 and 2.502 �� 0.1931, respectively; Supplemental Table 1). The total TNC scores of the metastatic and non-metastatic group are higher than that of the normal selleck chemicals llc tissues (scored 0.588 �� 0.1043; Figure 1B). A similar TNC expression trend was found in cancer cell and in mesenchyme in both metastatic and non-metastatic groups, respectively (Supplemental Table 1). Thus, these results suggest that high TNC expression was associated with metastasis potential. Figure 1 The association of TNC Expression and inflammation in HCC patients and Kaplan-Meier survival curves for all HCC patients with different TNC expression levels. A. TNC was detected by immunohistochemistry in normal liver tissues and in HCC tissues with Capmatinib price ... To determine the relationship between inflammation and TNC expression, Knodell score system was applied to assess the inflammation level. The results showed a higher inflammation score in metastatic HCC group compared to that in the non-metastatic group (12.72
�� 3.39 and 8.58 �� 2.52, respectively; Supplemental Table 1). Correlation analysis of total TNC scores was performed. There was a close association between total TNC scores and Knodell scores (Figure 1C, spearman��s rho = 0.547, P < 0.01). Thus, TNC expression was associated with inflammation in the liver tissue in HCC patients. A post-surgery follow-up was conducted to evaluate the relationship between patient survival and TNC expression. Patients were classified into three groups according to the deposition of TNC in cancer cell or in mesenchyme: cancer cell positive/mesenchyme positive (CaC+/M+, 60 patients), cancer cell positive/mesenchyme negative (CaC+/M-, 21 patients) and cancer cell negative/mesenchyme negative (CaC-/M-, 19 patients). During the follow-up, 48 patients in CaC+/M+ group, 7 patients in CaC+/M- group and 2 patients in CaC-/M- group have died. There was a significant difference among the three groups (��2 = 29.750, P < 0.05) (see Supplemental Table 2). Kaplan-Meier survival curves indicated that patients in CaC+/M+ group had the shortest median survival time (17 months). The patients in CaC+/M- group survived longer (32 months) (Figure 1D).